Today, researchers are keenly interested in both fast and high resolution separations of numerous biomolecules to support the development of novel therapeutic proteins and peptides in pharmaceutical drug development, to advance understanding in modern university laboratories, to characterize protein post-translation modifications, and to fully assess subtle differences in biosimilars and other products of bioengineering and manufacture.
HALO BioClass columns have been developed to make such tasks easier and more effective, and are aimed at the following areas of bioseparations:
- Intact proteins, monoclonal antibodies (mAbs), biosimilars, and other large biomolecules such as pegylated proteins, antibody drug conjugates (ADCs), etc.
- Peptide mapping (analysis of enzyme digests) for characterization and monitoring of synthetic protein drugs
- Analysis of therapeutic peptides and peptide biomarkers (protein surrogates)
- High resolution separations of complex mixtures of glycans released from N- and O-linked glycoproteins
Bioclass Column Specification Table