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HALO^® Fused-Core^® Performance

High Speed Separations

Smaller reduced plate heights lead to high efficiencies; narrower and taller peaks, for improved resolution and lower detection limits (LODs and LOQs)
Flat van Deemter plot and higher linear velocity optimum allow higher flow rates with minimal column efficiency loss

High Resolution Separations

High efficiency with longer geometries (100, 150, 250 mm)
provides greater resolving power for challenging applications
Lower back pressure permits columns to be used in series for the most demanding UHPLC and HPLC separations

Excellent Ruggedness and Reproducibility

Less plugging, longer usable column lifetime and greater uptime due to larger porosity frits (vs. sub-2 µm totally porous (non-core) columns)
- 2 µm frits for HALO® 2.7 and HALO 5
- 1 µm frits for HALO® 2 vs. 0.2–0.5 µm frits for sub-2 µm non-core columns
Excellent column-to-column and lot-to-lot reproducibility

Scanning Electron Microscope (SEM) image of HALO 2 particles. The particle size distribution is very narrow due to the separate sizing steps for solid cores and finished Fused-Core silica particles.

SEM image of a focused-ion-beam-cleaved HALO Protein 1000Å 2.7 µm silica particle. This “cut-away” view shows the solid core with its outer porous layer.

Performance vs. non-core Columns

Van Deemter Plot of Plate Height vs. Linear Velocity (flow rate)

Additional Resources

UltraFast Peptide Separation

Ultrafast Ballistic Gradient using HALO 5

Carbonyl-DNPH High Resolution Separation