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HALO® Fused-Core® Performance

High Speed Separations

  • Smaller reduced plate heights lead to high efficiencies; narrower and taller peaks, for improved resolution and lower detection limits (LODs and LOQs)
  • Flat van Deemter plot and higher linear velocity optimum allow higher flow rates with minimal column efficiency loss

High Resolution Separations

  • High efficiency with longer geometries (100, 150, 250 mm)
    provides greater resolving power for challenging applications
  • Lower back pressure permits columns to be used in series for the most demanding UHPLC and HPLC separations

Excellent Ruggedness and Reproducibility

  • Less plugging, longer usable column lifetime and greater uptime due to larger porosity frits (vs. sub-2 µm totally porous (non-core) columns)
    • 2 µm frits for HALO® 2.7 and HALO 5
    • 1 µm frits for HALO® 2 vs. 0.2–0.5 µm frits for sub-2 µm non-core columns
  • Excellent column-to-column and lot-to-lot reproducibility
Scanning Electron Microscope (SEM) image of HALO 2 particles. The particle size distribution is very narrow due to the separate sizing steps for solid cores and finished Fused-Core silica particles.
SEM image of a focused-ion-beam-cleaved HALO Protein 1000Å 2.7 µm silica particle. This “cut-away” view shows the solid core with its outer porous layer.

Performance vs. non-core Columns

Van Deemter Plot of Plate Height vs. Linear Velocity (flow rate)

Additional Resources

UltraFast Peptide Separation
Ultrafast Ballistic Gradient using HALO 5
Carbonyl-DNPH High Resolution Separation

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Our Products

  • HALO 2
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  • HALO 5
  • HALO Protein
  • HALO Peptide
  • HALO Glycan

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